Judith Klein-Seetharaman

TEMPE Campus
TEMPE Campus


Judith Klein, Professor in the School of Molecular Sciences and College of Health Solutions, obtained her PhD with late Nobel Laureate Har Gobind Khorana at Massachusetts Institute of Technology on conformational changes and folding in the G protein coupled receptor, rhodopsin. She holds dual undergraduate degrees in Biology and Chemistry from the University of Cologne, Germany.

Professor Klein’s research combines computational and experimental studies of protein structure, dynamics and function with particular emphasis on membrane proteins. She has published over 150 papers and has received a number of awards including the FP7 People Funded Marie Curie International Incoming Fellowship, the Sofya Kovalevskaya Award of the Humboldt Foundation, a Bill and Melinda Gates Foundation Grand Challenges Award, National Science Foundation CAREER Award and the Margaret Oakley Dayhoff Award of the Biophysical Society for her “remarkable work in computational biology embracing the full spectrum of experimental biophysics.”


PhD Massachusetts Institute of Technology

Google Scholar


The >160 peer-reviewed papers I have published are organized in the following areas and one example publication in each area is linked below:

  • Corals 

Kumar et al. (2021) Transfer of Knowledge from Model Organisms to Evolutionarily Distant Non-Model Organisms: The Coral Pocillopora damicornis Membrane Signaling Receptome, Biorxiv: https://www.biorxiv.org/content/10.1101/2021.10.18.464760v2.full.pdf

  • Obesity and Biosensing

Kumar et al. (2021) Structure-based survey of ligand binding in the human insulin receptor (2020) British Journal of Pharmaoclogy: https://doi.org/10.22541/au.162245427.70273837/v1

  • Lipids 

Planas-Iglesias, J. et al. (2015) Cardiolipin Interactions with Proteins. Biophys. J.: https://www.sciencedirect.com/science/article/pii/S0006349515007699?via%3Dihub 

  • G protein coupled receptor structure and dynamics

Mitchell et al. (2019) Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin, Plos ONE: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214639 

  • Non-GPCR protein structure and dynamics

Evans et al. (2021) Similarity of the non-amyloid-β component and C-terminal tail of monomeric and tetrameric alpha-synuclein with 14-3-3 sigma. Computational and Structural BIotechnology Journal:  https://www.sciencedirect.com/science/article/pii/S2001037021003962?via%3Dihub

  • Carbon nanotubes and biopolymers 

Kagan et al. (2010) Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation, Nature Nanotechnology: https://www.nature.com/articles/nnano.2010.44

  • Sequence analysis and bioinformatics 

Kshirsagar et al. (2021) Protein sequence models for prediction and comparative analysis of the SARS-CoV-2 —human interactome. Pacific Symposirum on Biocomputing: https://www.worldscientific.com/doi/abs/10.1142/9789811232701_0015

  • Protein-protein interactions and systems biology 

Qi et al. (2009) Systematic prediction of human membrane receptor interactions. Proteomics:  https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/pmic.200900259

  • Photosynthesis

De Las Rivas et al. (1995) pH sensitivity of the redox state of cytochrome b559 may regulate its function as a protectant against donor and acceptor side photoinhibition. Photosynthesis Research: https://link.springer.com/article/10.1007%2FBF00020430

  • Education

Leuba et al. (2014) Early integration of the individual student in academic activities: a novel classroom concept for graduate education in molecular biophysics and structural biology. BMC Biophysics: https://bmcbiophys.biomedcentral.com/articles/10.1186/2046-1682-7-6


numerous committees, review panels, ad hoc reviews, outreach activities, women in science

Expertise Areas

Page updated on Nov 27, 2021 9:45 am MST